Innovation in regenerative medecine

Transfer of technology

biomedical research

SILTISS was created in 2016 following the granting of an exclusive license to use four patents developed by Inserm laboratories U1148 (Paris) and U1026 (Bordeaux). The latter concern an innovative technology in the field of tissue engineering, namely the production of natural hydrogels, formed using non-animal materials. These hydrogels can be modified to address different tissues such as bone or skin. This technology has also led to numerous scientific publications.

This major technology transfer from public research to industry, in close collaboration with Inserm teams, allows SILTISS to benefit from the expertise of high-level researchers and specialists in the field of tissue engineering, in order to lead optimally the development of these new biomaterials.

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Product

biomaterials for guided bone regeneration

For its first product (GlycoBone®), SILTISS has chosen a development for bone reconstruction.

Bone is a tissue composed of two phases: a matrix mainly constituted of collagen and an inorganic phase composed of calcium and phosphates.

The approach provided by SILTISS is to draw inspiration from living organisms, by creating a product that comes as close as possible to the natural composition of bone, namely a biodegradable matrix of polysaccharides that supports the inorganic phase. This bone substitute is in the form of microbeads with controlled micro-porosity, injected as a non-curing paste.

This form allows GlycoBone® to have both micro- (intra-ball) and macrometric (inter-ball) porosities that promote cellular colonization and revascularization. In addition, since the inorganic phase consists of non-stœchiometric hydroxyapatite, this latest generation bone substitute has all the properties necessary for quality bone reformation, meaning osteoinduction, osteoconduction and osteointegration.

Publications

excellence in research

Maurel DB, Fénelon M, Aid-Launais R, Bidault L, Le Nir A, Renard M, Fricain JC, Letourneur D, Amédée J, Catros S.
Bone regeneration in both small and large preclinical bone defect models using an injectable polymer-based substitute containing hydroxyapatite and reconstituted with saline or autologous blood.
Journal of Biomedical Materials Research
2021;1-9

Grenier J, Duval H, Barou F, Lv P, David B, Letourneur D.
Mechanisms of pore formation in hydrogel scaffolds textured by freeze-drying.
Acta Biomater.
2019;94:195-203

Lanouar S, Aid-Launais R, Oliveira A, Bidault L, Closs B, Labour MN, Letourneur D.
Effect of cross-linking on the physicochemical and in vitro properties of pullulan/dextran microbeads.
J Mater Sci Mater Med.
2018;29:77

Fricain JC, Aid R, Lanouar S, Maurel DB, Le Nihouannen D, Delmond S, Letourneur D, Vilamitjana JA, Catros S.
In vitro and in vivo design and validation of an injectable polysaccharide-hydroxyapatite composite material for sinus floor augmentation.
Dental Materials.
2018;34:1024-1035

Ribot EJ, Tournier C, Aid-Launais R, Koonjoo N, Oliveira H, Trotier AJ, Rey S, Wecker D, Letourneur D, Vilamitjana JA, Miraux S.
3D anatomical and perfusion MRI for longitudinal evaluation of biomaterials for bone regeneration of femoral bone defect in rats.
Scientific Reports.
2017;7:6100.

Ehret C, Aid-Launais R, Sagardoy T, Siadous R, Bareille R, Rey S, Pechev S, Etienne L, Kalisky J, de Mones E, Letourneur D, Vilamitjana JA.
Strontium-doped hydroxyapatite polysaccharide materials effect on ectopic bone formation.
Plos One
2017;12:e0184663.

Guerrero J, Oliveira H, Catros S, Siadous R, Derkaoui S-M, Bareille R, Letourneur D, Amedee J.
The use of total human bone marrow fraction in a direct three-dimensional expansion approach for bone tissue engineering applications: Focus on angiogenesis and osteogenesis.
Tissue Engineering Part A.
2015;21:861-874

Schlaubitz S, Derkaoui SM, Marosa L, Miraux S, Renard M, Catros S, Le Visage C, Letourneur D, Amedee J, Fricain J-C.
Pullulan/dextran/nHA macroporous composite beads for bone repair in a femoral condyle defect in rats.
Plos One.
2014;9:e110251

Fricain JC, Schlaubitz S, Le Visage C, Arnault I, Derkaoui SM, Siadous R, Catros S, Lalande C, Bareille R, Renard M, Fabre T, Cornet S, Durand M, Leonard A, Sahraoui N, Letourneur D, Amedee J.
A nano-hydroxyapatite - pullulan/dextran polysaccharide composite macroporous material for bone tissue engineering.
Biomaterials
2013;34:2947-2959